Valutazione della guarigione dei siti postestrattivi mediante l’utilizzo di un gel a base di aminoacidie sodio ialuronato. Evaluation of post-extraction sites healing through the application of a gel based on amino acids and sodium hyaluronate

OBJECTIVES. The aim of this study was to compare both oral soft and hard tissue wound healing with and without use of a compound gel containing amino acids and sodium hyaluronate and to evaluate post-operative pain after tooth extraction. MATERIALS AND METHODS. 46 patients were divided into two groups (study group 23 patients and control group 23 patients). In the first group, the gel containing amino acids and sodium hyaluronate (Aminogam®, Errekappa Euroterapici SpA, Milano, Italy) was administered for the whole healing period, while in the second group, no topical substances were applied. Numeric Rating Scale (NRS, 0-10) was used to evaluate pain experienced after surgery. Using millimeter grid paper as a benchmark and a graphic software, Adobe Photoshop®, it was possible to measure the whole surgical wound area, immediately after tooth extraction (Timing 0), at 7 (Timing 1), 30 (Timing 2) and 60 days (Timing 3). RESULTS. The cases treated with the compound gel (study group) showed a higher average percentage of healing than the control group, with regard to both soft and hard tissue. NRS pain scale did not show any significant differences between the two groups. CONCLUSIONS. The use of a gel containing amino acids and sodium hyaluronate promoted a better and faster healing, both of the oral soft tissues, by reducing the surgical wound area in the first week after tooth extraction, and of the hard tissues, through the progressive filling of post-extraction alveoli. Introduction. Hyaluronic Acid is an extracellular constituent of the connective tissue that belongs to the family of glycosaminoglycans; it promotes and accelerates the healing process of surgical wounds through the stimulation of fibroblasts, collagen synthesis, remodeling of the extracellular matrix and the production of angiogenic cytokines. The aim of this study was to compare both oral soft and hard tissue wound healing with and without use of a compound gel containing aminoacids and sodium hyaluronate (Aminogam®, Errekappa, Italy) and to evaluate the post-operative pain after tooth extraction. Materials and methods. Patients were divided into two groups (study group and control group). In the first group, the gel containing amino acids and sodium hyaluronate was administered for the whole healing period, while in the second group, no topic substances were applied. Numeric Rating Scale (NRS, 0-10) was used to evaluate pain experienced after surgery. Using millimetrated grid as a b